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Present
Address:Physics Department
University of Mainz
Staudingerweg 7
55099 Mainz, Germany
Past Position:
Research Interests:
Full Curriculum Vitae
Postdoctoral Scientist (Prof. Fersht’s group)
Theoretical and computational approaches to protein folding and dynamics
(pdf)
PUBLICATIONS
2010
24. Svava K. Wetzel, Christina Ewald, Simon
Jurt, Giovanni Settanni, Andreas Plückthun and Oliver Zerbe.
Residue-resolved stability of full-consensus ankyrin repeat proteins probed by NMR.
J. Mol. Biol., in press
Residue-resolved stability of full-consensus ankyrin repeat proteins probed by NMR.
J. Mol. Biol., in press
23. Serquera D., Lee W., Settanni G., Paci
E., Marszalek P.E., Itzhaki L.S.
Mechanical unfolding of an ankyrin repeat protein.
Biophys. J., 2010 98(7):1294-301
Mechanical unfolding of an ankyrin repeat protein.
Biophys. J., 2010 98(7):1294-301
22. Basse N., Kaar J.
L., Settanni G., Joerger A. C., Rutherford T. J., Fersht A. R.
Towards the Rational Design of p53 Stabilizing Drugs: Probing the Surface of the Oncogenic Y220C Mutant
Chemistry & Biology, 2010 17(1):46-56
Towards the Rational Design of p53 Stabilizing Drugs: Probing the Surface of the Oncogenic Y220C Mutant
Chemistry & Biology, 2010 17(1):46-56
2009
21. Huang F., Rajagopalan S., Settanni S., Marsh R., Armoogum D., Nicolaou N., Bain A., Lener E., Haas E., Ying L., Fersht A. R.
Multiple conformations of full-length p53 detected with single-molecule fluorescence resonance energy transfer.
Proc. Natl. Acad. Scie. USA, 2009 106(49):20758-20763
Downhill versus barrier-limited folding of BBL 3. Heterogeneity of the native state of the BBL peripheral subunit binding domain and its implications for folding mechanisms.
J. Mol. Biol. 2009 387(4):993-1001
Structure of human MDM4 N-terminal domain bound to a single-domain antibody.
J. Mol. Biol. 2009 385(5):1578-89.
2008
High Temperature Unfolding Simulations of the TRPZ1 peptide
Biophys. J. 2008 94(11):4444-53
17. Huang F., Settanni G., Fersht A. R.
Fluorescence resonance energy transfer analysis of the folding pathway of Engrailed Homeodomain.
Protein Eng. Des. Sel. 2008 21(3):131-46
16. Wetzel S.K., Settanni G., Kenig M., Binz K., Plückthun A.
Folding and Unfolding Mechanism of Highly Stable Full Consensus Ankyrin Repeat Proteins
J. Mol. Biol. 2008 376(1):241-57
15. Interlandi G., Wetzel S.K., Settanni G., Plückthun A., Caflisch A.
Unfolding of designed ankyrin repeat proteins characterized by molecular dynamics simulations and chemical denaturation experiments
J. Mol. Biol. 2008 375(3):837-54
2007
14. Rao F., Settanni G., Caflisch A.
Estimation of folding probabilities and phi values from molecular dynamics simulations of reversible Peptide folding.
Methods Mol Biol. 2007; 350:225-49.
13. Seeber M., Cecchini M., Rao F., Settanni G., Caflisch A.
Wordom: a program for efficient analysis of molecular dynamics simulations
Bioinformatics. 2007 23(19):2625-7
2006
12. Interlandi G., Settanni G., Caflisch A.
Unfolding transition state and intermediates of the tumor suppressor p16INK4a investigated by molecular dynamics simulations.
Proteins. 2006 Jul 1;64(1):178-92.
2005
11. Rao F., Settanni G., Guarnera E., Caflisch A.
Estimation of protein folding probability from equilibrium simulations.
J. Chem. Phys., 2005, 122:184901
10. Settanni G., Rao F., Caflisch A.
Phi-value analysis by molecular dynamics simulations of reversible folding
Proc. Natl. Acad. Scie. USA, 2005, 102:628-33.
2004
9. Settanni G., Gsponer J., Caflisch A.
Formation of the folding nucleus of an SH3 domain investigated by loosely coupled molecular dynamics simulations
Biophys J. 2004; 86:1691-1701
2003
8. Uk B., M. Taufer, T. Stricker, G. Settanni, A. Cavalli, A. Caflisch: Combining Task- and Data Parallelism to Speed up Protein Folding on a Desktop Grid Platform
Proc. of the CCGRID 2003, IEEE International Symposium on Cluster Computing and the Grid, May 2003, Tokyo, Japan.
7. Settanni G., Cattaneo, A., Carloni P.
Molecular Dynamics Simulations of the NGF / TrkA domain 5 Complex and Comparison with Biological Data
Biophys J. 2003 84(4): 2282-92 (download)
6. Uk B., M. Taufer, T. Stricker, G. Settanni, A. Cavalli
Implementation and Characterization of Protein Folding on a Desktop Computational Grid
Proc. of IPDPS 2003, IEEE/ACM International, Parallel and Distributed Processing Symposium, April 2003, Nice, France.
2002
5. Settanni, G., Hoang, T.X., Micheletti, C., Maritan, A.
Folding Pathways of Prion and Doppel
Biophys. J. 2002 83 (6): 3533-42 (download)
4. Visintin, M., Settanni, G., Graziosi, S., Maritan, A., Marks, J.D., Cattaneo, A.
The intracellular antibody capture technology (IACT): towards an optimal consensus sequence for intracellular antibodies.
J. Mol. Biol. 2002 317 (1): 73-83 (download)
2001
3. Settanni G, Cattaneo A, Maritan A
The role of native-state topology in the stabilization of intracellular antibodies
Biophys. J. 2001 81: 2935-2945 (download)
2000
2. Dima RI, Settanni G, Micheletti C, Banavar JR, Maritan A
Extraction of interaction potentials between amino acids from native protein structures
J Chem Phys 112: (20) 9151-9166 May 22 2000 (download) (condmat)
1. Settanni G, Treves A
Analytical model for the effects of learning on spike count distributions
Neural Comput 12: (8) 1773-1787 Aug 2000 (download) (draft)
PATENTS
Intracellualr Antibodies. 2003. Patent Application. Patent number WO03014960.