Our major research programme concerns the folding, stability and activity of proteins, and the engineering of antibodies. We apply a broad multi-disciplinary approach that combines methods and ideas of molecular genetics and physical-organic chemistry. We use techniques including protein engineering, DNA cloning, sequencing and mutagenesis, gene and peptide synthesis, spectroscopy, rapid reaction techniques, multi-dimensional NMR and x-ray protein crystallography.

Current major projects include: understanding the pathway of protein folding; basis of molecular recognition; molecular chaperones; methods of renaturation of proteins; protein design; and structure-activity relationships of proteins involved in cancer and disease; the mapping, cloning and sequencing of human V-genes; the analysis of the sequences of natural human antibody repertoirs; the synthesis of human antibody repertoirs on phage with useful activities; the endowing of antibody fragments with effector functions; the engineering of antibody fragments for intracellular expression.
Read more...